Septerna, Inc. (SEPN)

Septerna, Inc. at a glance — key fundamentals, SEC filings, insider buying and selling, and earnings dates.

Septerna, Inc. (SEPN) is a Biotechnology company based in US with a market capitalization of $1.4B. Revenue grew 4174.5% year-over-year and the company generated $109.7M in free cash flow. This page tracks SEPN's SEC filings, insider buying and selling, earnings dates, and key fundamentals in one place.

US · 75 employees · IPO Oct 25, 2024

Valuation

Valuation & price

$26.95as of May 17, 2026· -27.8% vs 52w high

P/E ratio

Latest-FY diluted EPS

3.57

P/B ratio

Market cap ÷ book equity

Dividend yield

Price — last 12 months

$37.34$24.10$10.85Jul 25Dec 25Jul 26
$10.8552-week range$37.34
Loading valuation history…

Fundamentals

Key fundamentals

$1.4B

Market cap

4174.5%

Revenue growth (YoY)

100.0%

Gross margin

$109.7M

Free cash flow (USD)

-$367.5M

Net debt

Net cash position

19.0%

Share dilution

1/4

Graham criteria passed

Defensive-investor screen

Healthcare

Sector

Trajectory

Long-term trends

Revenue by year

20232025

$151K$46M

Free cash flow by year

20222025

-$24.6M$109.7M

Gross margin by year

20232025

100.0%100.0%

Value screen

Graham defensive-investor tests

Computing the scorecard — refreshing any stale inputs…

0

Insider buys · 90 days

7

Insider sells · 90 days

Earnings

Last report: 10-Q filed May 11, 2026

Next expected: not yet scheduled

On the tape

Recent SEC & insider activity

  • Insider sellJul 2, 2026Filing

    Insider Sell $115K · 10b5-1 PlanLong Daniel D. · SVP, Drug Discovery · $114.5K

  • Insider sellJun 30, 2026Filing

    Insider Sell $77K · 10b5-1 PlanShaikhly Samira · Chief People Officer · $76.6K

  • 8-K eventJun 30, 2026Filing

    Director Election and Auditor Ratification

  • Insider sellJun 24, 2026Filing

    Insider Sell $533K · 10b5-1 PlanLong Daniel D. · SVP, Drug Discovery · $532.6K

  • Insider sellJun 16, 2026Filing

    Insider Sell $219K · 10b5-1 PlanShaikhly Samira · Chief People Officer · $219.2K

  • Insider sellJun 3, 2026Filing

    Insider Sell $172K · 10b5-1 PlanShaikhly Samira · Chief People Officer · $171.7K

  • Insider sellMay 28, 2026Filing

    Insider Sell $355K · 10b5-1 PlanShaikhly Samira · Chief People Officer · $354.7K

  • 8-K eventMay 11, 2026Filing

    Earnings Release

  • Quarterly reportMay 11, 2026Filing

    10-Q Filed

  • Insider sellApr 17, 2026Filing

    Insider Sell $97K · 10b5-1 PlanBhatt Elizabeth · President and COO · $97.3K

Questions

Frequently asked questions

What is Septerna, Inc.'s market cap?

Septerna, Inc. (SEPN) has a market capitalization of $1.4B.

What is SEPN's P/E ratio?

A meaningful P/E ratio is not available for SEPN — the company's latest fiscal-year earnings per share is zero, negative, or not yet cached.

What is SEPN's price-to-book (P/B) ratio?

SEPN trades at 3.57 times book value per share.

Are insiders buying SEPN stock?

SEC Form 4 filings show no open-market insider buys at Septerna, Inc. in the last 90 days (7 sells).

Same arena

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Timeline

Every filing, insider trade & earnings on a price-anchored timeline

Filing Analyzer

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News

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Data: SEC EDGAR filings and cached fundamental data; prices and ratios use the most recent cached quote and statements (may lag by up to a day). Educational and research purposes only. Not investment advice.